After my negative, we did ERA and had a hysteroscopy to correct a small septum. Might be worth asking about. For the successful ivf only ONE healthy embryo is enough. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Thanks for commenting! We were eager to get going and my lining thickness/bloodwork looked good, so our doctor had allowed us to transfer one of our PGS embryos from Round 1 after our Round 2 retrieval. Hopefully an ERA can shed some light on it! PGT-A is generally recommended for women >35, and the majority of cycles in the US in 2020 were for women >35 (62%). Or they did but they were all aneuploid? Single embryo transfer both times. I haven't done the transfer yet due to various reasons, and even though nothing is guaranteed, I like going into it knowing that I have a better chance because it is a normal embryo. How did your pregnancy turn out? Note that this paper is still preprint as of Nov 2021. He earned his MSc in 2012 for his research on inflammation and lung cancerand started Remembryo in 2018 to help people understand the evidence behind common IVF topics. Can I ask why they didn't test them on Day 5? Im sorry to hear that. Your clinic may have a better idea of how things work in their hands. And mosaics are in between, with low/moderate level mosaics (<50% aneuploid cells) performing nearly the same as euploids. 4 PGT-M and PGT-A vs. Prenatal Testing What are the differences between the two tests? Did you carry to full term? Im going to try and run it by her again to see what she thinks. Liebermann et al. Gearing up for FET In my case, my miscarriage was potentially caused by a partial uterine septate that my doctor identified via sonohystergram and removed via hysteroscopy. I took the year off to just work on myself and be in a better mental state. My current success was a FET with NO meds except vaginal progesterone. 5AB euploid embryo. Congratulations on your success , I have a similar story. So mosaics can have a varying rates of miscarriage depending on the type of abnormality present. Please specify a reason for deleting this reply from the community. Comprehensive Chromosome Screening (CCS) is one technique of PGT-A that can identify whether an embryo is XX (female) or XY (male). So the next step is transfer and my clinic is telling me to go for era in order to increase my chances. no, I just took those 3. I'm super bummed about it being a chemical, but I still feel like progress was made because this was my first positive pregnancy test EVER. This can be done! For more background info, check out my post onPGS Testing. Chemical pregnancy with PGS tested embryo. We have one day 7/Euploid Blast 5BB remaining on ice. An embryo with more or fewer than 23 chromosome pairs may be at increased risk of miscarriage or certain genetic disorders. Hello- I will say that I have heard a LOT of stories of people having failures with PGS embryos followed by successes- on here and on instagram. They havent discontinued my medication they want me to continue until further instructions. Our RE recommends trying again, but it feels like insanity to try the same thing without changing/adding anything or doing some tests. In this case the clinic will need to: So the embryo would have to go through multiple rounds of freezing/thawing/biopsy, and this might have an impact on its potential. (2018)looked at about 650 transfers ofPGS tested euploidembryos (based onSNPtechnology) across various ages: So it looks like the success rates hover around 60-70% in most cases, with women >42 having about a 50% live birth rate per transfer. The FET process can take a few tries even with a PGS tested embryo. For these groups, about 50% of biopsies had noeuploidembryos. For the autoimmune stuff above I was tested by Alexander Kofinas. I also want to add low dose prednisone and lovenox - I have heard from so many of you that even IF no autoimmune issues are found that this combo helps. I didnt realize you could transfer your embryos to another clinic. However, another doctor (2nd opinion) claimed that Receptiva would only be conducted for implantation failure and for those who had never seen positive pregnancy tests. Hi lovely people , as per your recommendations I went for another egg retrieval and did pgs testing on 3 embryos out of which 2 came back normal. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. I know how devastating loss can be but theres always, always hope. Best of luck to you with your upcoming FET, my thoughts and prayers are with you! We were hoping for a Christmas miracle however that was short lived. With the retrieval statistics, we can include all cycles (like the ones that ended with no blasts to transfer or only abnormal embryos that werent transferred) and that lowers the success rates quite a bit. After a chemical with 2 PGS normals and two miscarriages around 8 weeks (spontaneous pregnancies) and another failed transfer, I found out I had an infection in my lining that can only be detected by a biopsy. We spent well over 45K to get to this point. The results come back as euploid (meaning theres 46 chromosomes), aneuploid (meaning theres a number of chromosomes besides 46) or mosaic (meaning theres a mix of euploid and aneuploid cells). He suggested an endometrial biopsy instead. sd84. I cannot even imagine how it mustve been to go through all of that but Im happy to hear you finally got your miracle!!! Ive had two biochemical losses with day 6 4BC euploids and with 1 day 6 4BC left to try, Im wondering our odds. An embryo forms and may even embed in your uterus lining (implantation), but then it stops developing. After I had my 3rd, my doctor and the IVF nurses all pushed for an ERA saying that even though Ive had prior success, that may have just been luck and my optimal window might be different than what I was doing. Jun 13, 2021 2:33 PM It is looking like we will have a second consecutive blighted ovum with a PGS normal embryo. Good luck. Now I wonder if that could have been the culprit. But wait! Ive seen conflicting studies with some (irani 2017) saying poor quality euploid has just 25% LBR but some more recent studies (2021) that suggest that morphology matters more under 30 (which Im not Im 42 but was 37/8 at retrieval). Last year I got pregnant from an IUI and miscarried at 8 weeks. Its good you will request the endomitritis biopsy. If I had transferred two without PGS, there would have been a significant chance that both would have been abnormal. I encourage to keep pushing forward. This ended up working for me after my biochemical pregnancy. Terms are highlighted every 3rd time to avoid repetition. Learn more about, Learn About What to Expect's Pregnancy & Baby App. We are absolutely crushed. 35 years old Unfortunately this isnt very clear at this point. As someone else mentioned adding prednisone, I also had a steroid but mine was the Medrol Dose pack which is basically the same idea. I went into my second egg retrieval and got less eggs than the first time around. Started with 14 eggs, 7 fertilized and only 1 made it to blast and ended up being abnormal. Its such a good point and one that is often missed, I think. There is much better chance of IVF success with PGS testing in women who were over the age of 35. Because all the women who didnt have embryos to transfer are now included and lower the overall success for that age group. I know how hard this all is. Hi! Thanks in advance! Is there any reasoning behind this- is it due to poor egg quality, poor sperm quality, or both? I also know that no one can make this decision for me. Out of the 6 that were pgs tested, 3 came back normal and 1 came back inconclusive. Did your doctor have your SO go through the rounds of antibiotics as well? I am 42. We were told not to worry and try again after a month, and in March I found I was pregnant again but this turned out to be a chemical pregnancy. I know PGS tested embryos can still have issues but its been 4 transfers now with no success so Im wondering if theres a deeper issue. What would they tell me and how would they impact protocol differently? I wanted to point out thestandard deviationof this data is large, roughly 30% for each group. According to the authors, the >35 group analysis should be interpreted with caution as the sample size was small. Ill also update this blog to include that info. I have had my heart broken multiple times. And Im so sorry about your first FET. So, all is well! I've experienced 3 chemical pregnancies - one naturally (7/2017), one via our 2nd IUI (9/2018), and the third this January after our FET with a PGS tested embryo. Recurrent Chemical Pregnancy - PGS embryo (and Donor egg ) Advice needed. Chemical pregnancies occur so early that many people who miscarry don't realize it. I dont know if this is helpful or not but Ive had 4 FETs. How about a mosaic? It would be a miracle to have a similar experience as yours , I know you said age is a factor, but you could always take a month or two off for your mental health and then re-assess. Is it because they were early blastocysts? My doctor is recommending a Receptiva test to uncover any other reasons why the pregnancies won't last. frustration and tears were worth it. Both Chemical pregnancies my lining was under 7. She said she is willing to do so but against her medical advice. 2018). We found out yesterday we were having a chemical pregnancy, my second beta didnt double. For that reason my RE said she would start testing such as ERA after a second failed transfer but didnt think it was necessary after the first failed transfer. Once I started hearing other people's stories I was shocked at how common it is- more so than I ever would have imagined. may be contradicted by other studies. I wanted to reach out and see if you know a way to find a surrogate on your own, rather than going thru an agency. Currently 8 weeks. More high quality studies need to be performed to really see the answer to this question. Obviously this is not an ideal situation but sometimes this happens. I honestly wish I had but thats all hindsight now knowing what I knew. Embryos with the right number of chromosomes are called euploid and may have a higher chance of making a pregnancy, although the evidence for this is controversial. There was a greater reduction in the >35 group (10.4% for PGT-A vs 27.9% for untested) compared to the <35 group (13.3% for PGT-A vs 16.1% for untested), however neither of these analyses were statistically significant. All that to say, it's likely that there actually was something wrong with that embryo - but it's worthwhile to leave no stone unturned before trying again. I had a PGT normal day 7 embryo that unfortunately resulted in a chemical. Saw a heartbeat at 6 and 8 weeks then nothing at week 10. Women above 35 seem to benefit the most with PGS . With a PGS tested embryo this time. He also answers questions in his private Facebook group. A genetically normal embryo has a 70% chance of a positive pregnancy test in any woman, whether she is 20 years old or 40 years old. My lining a week before transfer was 6.8, but trilaminar lining was present. I am remaining hopeful, when we sent our embryos for testing, they only thought that one would come back normal. I pay completely out of pocket for everything so the added expense was not something I wasnt looking forward to, but Im happy I went through with it. All genetically untested embryos. I'm doing the full "recurrent pregnancy loss" blood workup and karyotype genetic testing on my husband and me before we try again. My current doctor did mention surrogacy as well, especially since the embryo we brought over was our final attempt with IVF. Dr is responsible for allowing . They also provided information for the chance of getting no euploids per cycle: So as age increases, the chances of getting a euploid embryo drop. Chemical pregnancy is an early miscarriage. Im sorry for your loss My first was also a frozen transfer and I agree, there is more prep involved. In contrast to mosaic embryos that are a mix of euploid and aneuploid cells, aneuploid embryos are completely aneuploid and all the cells are abnormal. Other studies seem to suggest a 8-11% chance of miscarriage with a euploid transfer. Turns out I was 24 hours prereceptive and Im convinced the ERA and extra day of progesterone is what did it. I just found out today that I've only got 2 larger follicles and 3 smaller ones that are growing but are quite behind the 2 larger ones. I also stopped working night shifts (Im a nurse) to reduce my stress levels but that didnt help either. Success is still very possible, IVF treatments are often a trial and error situation as my doctor put it once. Because of my age and being diagnosed with diminished egg reserve we did "embryo batching" and I had 4 rounds of egg retrievals before moving onto any transfers. Overall, I really wish clinics and REs were more straightforward about odds of success esp with pgs since I think they can be a little misleading. The results came back just this week saying that I was "pre-receptive" and recommended one day more of progesterone before doing the transfer to get to a more "ideal" transfer state. Im so sorry to hear about your losses but so happy with your current miracle. Terms are highlighted every 3rd time to avoid repetition. Thats a great suggestion, I will definitely ask my dr about doing an ERA. Please whitelist our site to get all the best deals and offers from our partners. Have you ever had an endometrial biopsy to look for infection? We are currently waiting on the PGS results from the frozens from our third cycle. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. Objective: To determine whether undetected aneuploidy contributes to pregnancy loss after transfer of euploid embryos that have undergone array comparative genomic hybridization (aCGH). My husband and I started trying to get pregnant about a year ago (we're both 35). I am 39 turning 40 this year. I was told by my doctor that when it is a PGS embryo that is miscarried, it is a 50% chance it was something else with the embryo (structural issues with the organs or placenta) and a 50% chance it was something about the moms body. PGS/PGT-A success rates can vary. For more up-to-date information on this topic check out my other posts that are tagged withEmbryo rebiopsy. While those are great odds, sometimes the FET fails. I was exactly like you- I told myself and my RE that I refused to go through that devastation again so I wanted to do everything possible to make the outcome different. I also tested positive for anti-thyroid antibodies. It was a chemical pregnancy. Check here for the full glossary (please excuse the repeated terms!). Like embryo grades in the previous section, it looks like IVF with PGS success rates may vary based on how fast the embryo develops, particularly for Day 7. We put back a normal PGS tested embryo. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. They found a reduction in live birth rates (50% to 39%), although this was notstatistically significant(it was from a small study). However, almost all studies and clinic data show that IVF success rates indicates higher pregnancy rates. 2014). That sounds a lot like my dr. Its basically an assembly line in there. (2018)looked ateuploidembryos (aCGH/SNP) in women <35: Irani et al. And congrats on your little girl! Has anyone experienced a failure or chemical pregnancy when transferring a PGS normal embryo *AND* being on an autoimmune protocol? Multiple losses due to chromosomal abnormality, did you do ivf? A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. He also answers questions in his private Facebook group. Medication wise other than the standard progesterone and estrogen and prenatal I also did take aspirin 81mg. Sometimes something as small as a polyp that can be removed, can cause implantation to fail. So crazy that its what finally worked. A chemical pregnancy is a very early miscarriage that happens within the first five weeks of pregnancy. I had a chemical last November with a PGS normal embryo and was successful with the second FET in July. This is important because miscarriage rates with advancing female age. Can any further conclusion be made based on number of normal pgs results ? - 2 Day 5's transferred ended in a chemical pregnancy; 1 perfect Day 6 blast ended up making me a mom. Im trying not to fixate on my last embryo being a day 7. Yeah now Im just rethinking everything. Terms are highlighted every 3rd time to avoid repetition. If you have not I would suggest an embryo scratch/biopsy before your next FET. If it's any consolation, we also did acupuncture with the failed FET, but not the one that worked. thank you so much! We got to see and hear the heartbeat yesterday. If it were me and it was my last embryo I would definitely ask about (possibly even push for) immune protocol and the ERA just to cover all my bases. Then for my second FET we did an unmedicated FET and it worked. MENTS my FET following that one was successful and I am now 28 weeks pregnant END MENTS .This whole IVF journey takes so much out of you and I truly feel your pain but please keep trying. Lack of common pregnancy symptoms like morning sickness or breast soreness after a positive pregnancy test. She was also concerned with the previous doctors aggressive surgery protocols, and my age was also a factor. We had 4 blasts tested in our first IVF cycle and 2 were abnormal / 1 mosaic / and then 1 "normal". This educational content is not medical or diagnostic advice. Patients often hear "PGS-normal embryos have a 60 - 70% success rate." But that is on a per-transfer basis. I was more relaxed overall at the second transfer, and maybe that helped. Hi, i didnt have chemicals, I had bfn for my first two transfers. Seems to work for many, many women. We are at a loss as both embryos transferred (one late last year and one last month) were PGS normal. Some of the reasons quoted weren't even about the patient: it could have been damaged during the biopsy or thaw process in the lab, the transfer process could have been off, there's a margin of error with the testing itself, pgs doesn't tell us everything about an embryo, etc. Consult with your doctor before making any treatment changes. . By 40 theres about a 1 in 4 chance of not getting a euploid and by 43 this doubles to half. I guess I'm facing wasting the investments of stimulation vs potentially wasting the investments in proceeding but also getting more information that might help with future cycles. Sorry to hear about your recent cycle. So the advantage with PGT-A may be in determining which embryos are completely unfit for transfer, at least based on this study. Do embryo biopsies for PGT-A match the rest of the embryo? Im sure that data exists especially since thats how things used to be done back in the day. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Patient(s): Cases included 38 patients who underwent frozen euploid ET as determined by aCGH, resulting in miscarriage. So all the aneuploid embryos that were transferred either didnt implant, or miscarried. I may not have that exactly correct but thats how I understood it. There isnt much data on it, and 2 of the 3 studies found no difference, so it isnt exactly clear. undefined will no longer be visible to you including posts, replies, and photos. That embryo implanted but resulted in a chemical pregnancy. Check here for the full. Took THREE rounds of antibiotics for mine to clear. Feeling more confused than ever. thanks so much! Setting: University-based fertility center. Second, PGS speeds up the time to pregnancy. Very frustrating to have an inconclusive. I will ask my dr about this. Nov 2, 2016 8:12 AM. I agree with the others that you should push for some sort of testing or SOMETHING to investigate before trying again (if you haven't already). We had 30 eggs retrieval. Im sorry that didnt work. We did do some things differently, however my RE did these things more to appease me because he knew how frustrated I was than because he thought they were medically necessary. Most of the patients in the studies were <35. Trying to be strong and not make the holidays about my loss for the sake of my family, not sharing the news either until after. And I can't say thats the sole reason this one stuck, but it is the one thing we did differently, and here I am. Have you been tested for APS (antiphosolipid syndrome)? Talk about adjusting meds? It will involved thawing your embryos, biopsying, then re-freezing and ultimately re-thawing if the embryo is euploid and you want to transfer it. Try to take extra good care of yourself while you regroup from this cycle, and then go with your instincts for your next cycle. Any advice is greatly appreciated. Women who have three chromosomally-normal embryos as a result of In Vitro Fertilization (IVF) have a 94.9% chance of achieving pregnancy, research conducted by Reproductive Medicine Associates (RMA) and presented at the annual meeting of the American Society for Reproductive Medicine (ASRM) shows. I go for my next Beta tomorrow. If your protocol did not have one or the other perhaps you can ask your RE about it. Hi Mogwai_2 Theses are rates for PGS normal embryos. While my clinic has had great success with PGS transfers they did say they expect implantation rates to end up averaging 90% for PGS normal embryos and I believe miscarriage rates are also lower. If youre confused about the terminology youll see coming up, check my post on understanding PGS testing results. I am terrified he wont implant. in reply to 3 years ago Thank you so much! I completely understand struggling about whether to do the 3rd retrieval, it is a lot to go through all over again. Best of luck! Capalbo et al. It worked and now I'm 24 weeks pregnant with twins! They did blood tests after my miscarriage and my doctor said it was important to do it when my body still thought I was pregnant. I miscarried a genetically normal baby girl at 8.5 weeks and they tested me for autoimmune disorders so that could be something to check for as well. So sorry this happened and good luck to you. , thats definitely worth looking into as well! Wondering if anyones had a similar experience or has any advice. I just received news today that out of our 14 blastocysts only 4 passed pgs and 1 with no result that we are retesting. (2018)found a reduction in clinical pregnancy when embryos were thawed, biopsied and re-frozen (the odds were about half). MENTS I am also going through a chemical pregnancy this week, but with an untested embryo (so, that's very likely the reason for my loss). My first FET was a day 6 5AA euploid embryo. We had PGS/PGD testing and an ERA. I could tell that my dr thought we could just try again but she knew I needed to check something to feel ok with it. Did our first FET in October with a supposedly PGT normal embryo. I also had a chemical with a PGS tested embryo. (2017)found no difference in survival rates of embryos that were thawed and biopsied, then refrozen. I actually didnt have embryos to bring with me when we switched. Alternatively you can check out my websites tag for mosaic embryos here. Success rates with chromosomally normal embryos, complete guide to embryo grading and success rates, https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates, They also found that the chance of getting a complex abnormal embryo increased with age, Graded as excellent (AA) or good (AB or BA) = 50% live birth, Graded as excellent: 84%ongoing pregnancy, 0% miscarriage, Good: 62%ongoing pregnancy, 3% miscarriage, Poor: 36%ongoing pregnancy, 19% miscarriage, Thaw the embryo and culture it until it can be biopsied (this may take a few hours to a day), If the 2nd test comes back euploid and you transfer, another thaw will need to be done.